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AS601245

An ATP-competitive JNK inhibitor
Catalog #: 2162

In stock

SKU-Size Size Price Qty
2162-1 1 mg
$100.00
2162-5 5 mg
$245.00
More Sizes Get Quote

Product Details

Alternate Name (Z)-2-(Benzo[d]thiazol-2(3H)-ylidene)-2-(2-((-(pyridine-3-yl)ethyl)amino)pyridine-4-yl)acetonitrile
Appearance White to yellow solid
CAS # 345987-15-7
Molecular Formula C₂₀H₁₆N₆S
Molecular Weight 372.45
Purity ≥95% by HPLC
Solubility DMSO (10 mg/ml)
SMILES C1=CC=C2C(=C1)NC(=C(C#N)C3=NC(=NC=C3)NCCC4=CN=CC=C4)S2
InChi InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15+
InChi Key AVLYNJZZQYEFEA-XDJHFCHBSA-N
PubChem CID 11422035
MDL Number MFCD07772196
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. AS601245 is a potent, ATP-competitive JNK inhibitor (hJNK1: IC₅₀ = 150 nM, hJNK2: IC₅₀ = 220 nM and hJNK3: IC₅₀ = 70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.


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