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AS 604850

A selective, ATP-competitive inhibitor of PI3Kγ
Catalog #: 2339
SKU-Size Size Price Qty
2339-1 1 mg
2339-5 5 mg
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Product Details

Alternate Name 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
Appearance Off-white solid
CAS # 648449-76-7
Molecular Formula C₁₁H₅F₂NO₄S
Molecular Weight 285.22
Purity ≥98% by HPLC
Solubility DMSO (50 mg/ml) or Ethanol (5 mg/ml)
InChi InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-
PubChem CID 5287855
MDL Number MFCD19705528
Handling Protect from air and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. AS 604850 inhibits MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduces RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

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