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AS-252424

A PI3Kg/CKII Inhibitor
Catalog #: B1611

In stock

SKU-Size Size Price Qty
B1611-5 5 mg
$375.00
B1611-25 25 mg
$1,275.00

Product Details

Alternate Name AS-252424; AS 252424; AS252424; 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione; (E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; PI3Kg/CKII Inhibitor
Appearance Solid
CAS # 900515-16-4
Molecular Formula C₁₄H₈FNO₄S
Molecular Weight 305.3
Purity ≥98%
Solubility DMSO
SMILES C1=CC(=C(C=C1F)O)C2=CC=C(O2)C=C3C(=O)NC(=O)S3
InChi 1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6+
InChi Key OYYVWNDMOQPMGE-WUXMJOGZSA-N
PubChem CID 16757575
MDL Number MFCD11045281
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50=940 nM, PI3Kb IC50=20,000 nM and PI3Kd IC50= 20,000 nM respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50=230 nM. In a mouse model of peritonitis, PI 3-Kᵧ this compound inhibited neutrophil recruitment 35% at a dose of 10 mg/kg.


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