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AS-2444697 Hydrochloride

A potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor
Catalog #: B1585

In stock

SKU-Size Size Price Qty
B1585-5 5 mg
$195.00
B1585-25 25 mg
$775.00

Product Details

Alternate Name N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697
Appearance Crystalline solid
CAS # 1287665-60-4 
Molecular Formula C₉H₂₁ClN₆O₄
Molecular Weight 432.86
Purity ≥98% by HPLC
Solubility DMSO
SMILES Cl.Cc1nccc(c1)c2occ(n2)C(=O)Nc3cn(nc3C(N)=O)C4CCOCC4
InChi InChI=1S/C19H20N6O4.ClH/c1-11-8-12(2-5-21-11)19-23-15(10-29-19)18(27)22-14-9-25(24-16(14)17(20)26)13-3-6-28-7-4-13;/h2,5,8-10,13H,3-4,6-7H2,1H3,(H2,20,26)(H,22,27);1H
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AS-2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC₅₀ = 21 nM). It exhibits 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro.


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