You have no items in your shopping cart.
Product Details
| Size | 100 assay |
|---|---|
| Detection Method | Fluorescence (Ex/Em = 360/440 nm) |
| Species Reactivity | Mammalian |
| Applications | Measurement of NAT activity in tissue samples or purified protein |
| Kit Components | • NAT Assay Buffer
• NAT Substrate I • NAT Substrate II • DTT • Acetylated Standard • NAT Positive Control |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Arylamine N-acetyltransferases (NATs, EC 2.3.1.5) are a group of cytosolic, conjugating enzymes involved in phase II xenobiotic metabolism. They transfer an acetyl group from acetyl Coenzyme A to a xenobiotic acceptor substrate. There are two main isoforms, NAT1 and NAT2, which share about 81% amino acid sequence homology. NAT1 is widely expressed in all tissues whereas NAT2 is present primarily, in the liver and intestine. In addition to its role in xenobiotic metabolism, NAT1 plays an important role in folate metabolism. NAT2 is a polymorphic enzyme wherein the slow acetylator phenotype of NAT2 has been linked to urinary bladder cancer whereas the rapid acetylator phenotype has been linked to colorectal cancer. The slow acetylator phenotype has also been widely linked with toxicity due to isoniazid: a widely used tuberculosis drug. BioVision’s Arylamine N-acetyltransferase Activity Assay Kit is a simple, one step plate based assay that measures a fluorescent product. It can measure both NAT1 and NAT2 activity and can detect as low as 1 µU in samples.
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
