Product Details
| Alternate Name | (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 3beta-arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid; C20-FABAC; (3beta,5beta,7alpha,12alpha)-7,12-dihydroxy-3-(icosanoylamino)cholan-24-oic acid |
|---|---|
| Appearance | White Solid |
| CAS # | 246529-22-6 |
| Molecular Formula | C₄₄H₇₉NO₅ |
| Molecular Weight | 702.1 |
| Purity | ≥98% |
| Solubility | ~20 mg/ml in ethanol and DMSO, ~30 mg/ml in DMF |
| SMILES | CCCCCCCCCCCCCCCCCCCC(=O)NC1CCC2(C(C1)CC(C3C2CC(C4(C3CCC4C(C)CCC(=O)O)C)O)O)C |
| InChi | InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1 |
| InChi Key | SHKXZIQNFMOPBS-OOMQYRRCSA-N |
| PubChem CID | 18738120 |
| MDL Number | MFCD21608618 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It dissolves pre-existing cholesterol crystals in model bile solutions. It causes 70% to 83% inhibition of stearoyl coenzyme A desaturase 1 (SCD1) activity in vitro. Aramchol (0.5 mg or 1.0 mg/d) reduces the development of gallstones or cholesterol crystals in mice fed a lithogenic high-fat diet. It significantly reduces liver fat content in patients with nonalcoholic fatty liver disease.
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