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Aramchol

A synthetic fatty-acid/bile-acid conjugate (FABAC)
Catalog #: B3027
SKU-Size Size Price Qty
B3027-5 5 mg
$65.00
B3027-25 25 mg
$260.00
More Sizes Get Quote

Product Details

Alternate Name (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 3beta-arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid; C20-FABAC; (3beta,5beta,7alpha,12alpha)-7,12-dihydroxy-3-(icosanoylamino)cholan-24-oic acid
Appearance White Solid
CAS # 246529-22-6
Molecular Formula C₄₄H₇₉NO₅
Molecular Weight 702.1
Purity ≥98%
Solubility ~20 mg/ml in ethanol and DMSO, ~30 mg/ml in DMF
SMILES CCCCCCCCCCCCCCCCCCCC(=O)NC1CCC2(C(C1)CC(C3C2CC(C4(C3CCC4C(C)CCC(=O)O)C)O)O)C
InChi InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1
InChi Key SHKXZIQNFMOPBS-OOMQYRRCSA-N
PubChem CID 18738120
MDL Number MFCD21608618
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It dissolves pre-existing cholesterol crystals in model bile solutions. It causes 70% to 83% inhibition of stearoyl coenzyme A desaturase 1 (SCD1) activity in vitro. Aramchol (0.5 mg or 1.0 mg/d) reduces the development of gallstones or cholesterol crystals in mice fed a lithogenic high-fat diet. It significantly reduces liver fat content in patients with nonalcoholic fatty liver disease.


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