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AR-42 (HDAC-42)

A potent HDAC inhibitor
Catalog #: 2716
SKU-Size Size Price Qty
2716-1 1 mg
$95.00
2716-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide
Appearance Crystalline solid
CAS # 935881-37-1
Molecular Formula C₁₈H₂₀N₂O₃
Molecular Weight 312.36
Purity ≥98% by HPLC
Solubility DMSO (~ 20 mg/ml) or EtOH (~ 20 mg/ml
SMILES CC(C)C(C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO
InChi InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1
InChi Key LAMIXXKAWNLXOC-INIZCTEOSA-N
PubChem CID 6918848
MDL Number MFCD17676151
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AR-42 is a potent histone deacetylase inhibitor (HDACi). It induces growth inhibition, cell- cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 also promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21 and exhibits in vitro and ex vivo biologic activity against malignant mast cells.


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