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APY-0201

A potent, highly selective, ATP-competitive PIKfyve inhibitor
Catalog #: 9564
SKU-Size Size Price Qty
9564-5 5 mg
$125.00
9564-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name (E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine
Appearance White to off-white solid
CAS # 1232221-74-7
Molecular Formula C₂₃H₂₃N₇O
Molecular Weight 413.48
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES CC1=CC=CC(=C1)C=NNC2=NC3=CC(=NN3C(=C2)N4CCOCC4)C5=CC=NC=C5
InChi InChI=1S/C23H23N7O/c1-17-3-2-4-18(13-17)16-25-27-21-15-2
InChi Key RFZQYGBLRIKROZ-XYGWBWBKSA-N
PubChem CID 70941637
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC₅₀ = 5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. Also acts as a unique small molecular IL-12/23 production inhibitor.


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