Apremilast (ab285379)
Key features and details
- Potent inhibitor of PDE4
- CAS Number: 608141-41-9
- Purity: > 98%
DMSO (>80 mg/ml)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Apremilast -
Description
Potent inhibitor of PDE4 -
Biological description
Ppotent PDE4 (phosphodiesterase 4) inhibitor (IC50 = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.
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Purity
> 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 2352 Apremilast. 2352-25 is the same size as the 25 mg size of ab285379.
Protect from air and moisture.
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CAS Number
608141-41-9
Properties
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Chemical name
N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
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Molecular weight
460.50 -
Molecular formula
C22H24N2O7S -
PubChem identifier
11561674 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. -
Solubility overview
DMSO (>80 mg/ml)
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab285379 has not yet been referenced specifically in any publications.