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APP (His-tagged), human recombinant

APP functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides.
Catalog #: 7887
SKU-Size Size Price Qty
7887-10 10 μg
$155.00
7887-50 50 μg
$575.00
More Sizes Get Quote

Product Details

Alternate Name ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, Amyloid beta A4 protein
Gene Symbol APP
Gene ID 351
Accession # P05067
Source E. coli
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 34.7 kDa
Purity by SDS-PAGE >85%
Amino Acid Sequence Leu18 - Glu289
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

APP, also known as amyloid beta A4 protein, functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).


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