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Product Details
| Alternate Name | 4-[[2-[3,5-bis(trifluoromethyl) phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl] methyl]-benzamide, Apoptosis Activator VII |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1054543-47-3 |
| Molecular Formula | C₃₃H₂₅F₆N₃O₃ |
| Molecular Weight | 625.6 |
| Purity | ≥98% by HPLC |
| Solubility | >40 mg/ml in DMSO |
| SMILES | COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC |
| InChi | InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43) 31(41-28) 23-15-24(32(34,35)36)17-25(16-23) 33(37,38)39/h3-17H, 18H2, 1-2H3, (H2,40,43) |
| InChi Key | ZIMMTPFXOMAJTQ-UHFFFAOYSA-N |
| PubChem CID | 24894064 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively. Apoptozole dose-dependently induces apoptosis in cancer cells (IC₅₀ = 5-7 µM). It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.
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