A heat shock protein 70 (Hsp70) inhibitor
Catalog #: B2412 | abID: ab287038

Product Details

abID ab287038
Alternate Name 4-[[2-[3,5-bis(trifluoromethyl) phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl] methyl]-benzamide, Apoptosis Activator VII
Appearance Crystalline solid
CAS # 1054543-47-3
Molecular Formula C₃₃H₂₅F₆N₃O₃
Molecular Weight 625.6
Purity ≥98% by HPLC
Solubility >40 mg/ml in DMSO
SMILES COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
InChi InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43) 31(41-28) 23-15-24(32(34,35)36)17-25(16-23) 33(37,38)39/h3-17H, 18H2, 1-2H3, (H2,40,43)
PubChem CID 24894064
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively. Apoptozole dose-dependently induces apoptosis in cancer cells (IC₅₀ = 5-7 µM). It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.

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