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Product Details
| Alternate Name | 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione |
|---|---|
| Appearance | Orange solid |
| CAS # | 79183-19-0 |
| Molecular Formula | C₁₅H₉Cl₂NO₂ |
| Molecular Weight | 306.14 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~ 30 mg/ml) |
| SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl |
| InChi | InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2 |
| InChi Key | KGRJPLRFGLMQMV-UHFFFAOYSA-N |
| PubChem CID | 1901244 |
| MDL Number | MFCD00141556 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
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