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Apoptosis activator 2

An apoptosis activator
Catalog #: 2784

In stock

SKU-Size Size Price Qty
2784-5 5 mg
$85.00
2784-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Appearance Orange solid
CAS # 79183-19-0
Molecular Formula C₁₅H₉Cl₂NO₂
Molecular Weight 306.14
Purity ≥98% by HPLC
Solubility DMSO (~ 30 mg/ml)
SMILES C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl
InChi InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
InChi Key KGRJPLRFGLMQMV-UHFFFAOYSA-N
PubChem CID 1901244
MDL Number MFCD00141556
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).


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