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ApoJ/Clusterin, mouse recombinant

A heavily glycosylated protein upregulated in multiple pathological conditions
Catalog #: 7554
SKU-Size Size Price Qty
7554-10 10 μg
$240.00
7554-50 50 μg
$775.00
More Sizes Get Quote

Product Details

Alternate Name TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2, AAG4, KUB1, SGP2, SP-40, TRPM2, MGC24903.
Gene Symbol CLU
Gene ID 12759
Accession # Q06890
Source E. coli
Appearance Liquid
Physical Form Description 1 mg/ml of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
Molecular Weight ~45 kDa (SDS-PAGE). Mouse nuclear Clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
Purity by SDS-PAGE ≥90%
Endotoxin Level <1 EU/μg by LAL method
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.


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