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ApoE4, human recombinant

Apolipoprotein essential for the normal catabolism of triglyceride-rich lipoprotein constituents
Catalog #: 4699
SKU-Size Size Price Qty
4699-50 50 μg
$65.00
4699-100 100 μg
$80.00
4699-500 500 μg
$205.00
4699-1000 1 mg
$355.00
4699-5000 5 mg
$1,250.00
More Sizes Get Quote

Product Details

Alternate Name Apolipoprotein E4, APOE, apolipoprotein, apolipoproteins
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 34.4 kDa
Purity by SDS-PAGE ≥90%
Purity by ≥90%
Endotoxin Level <0.1 ng/μg
Reconstitution Instructions Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues (Accession No. AAB59397). This protein has a N-terminal His-tag.


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Geffin, Rebeca et al. (2017) Apolipoprotein E4 Suppresses Neuronal-Specific Gene Expression in Maturing Neuronal Progenitor Cells Exposed to HIV, J Neuroimmune Pharmacol. 2017 Mar 20.
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