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ApoE4 Antibody

Catalog #: 5699
SKU-Size Size Price Qty
5699-30T 30 µg
$95.00
5699-100 100 µg
$275.00
More Sizes Get Quote

Product Details

Antibody Target ApoE4
Alternate Name Apo-E4, ApoE4, Apo E4, ApoE4 Polyclonal Antibody, Anti-ApoE4 Polyclonal antibody, Anti-ApoE4, Apo, apolipoprotein, apolipoproteins
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant human ApoE4
Accession # AAB59397
Gene ID 178853
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation Supplied in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Human
Application Western blot
Application & Usage Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human ApoE4 (Cat.# 4699-50) can be used as a positive control.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease.


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