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ApoE2 Antibody

Catalog #: 5760
SKU-Size Size Price Qty
5760-30T 30 µg
$89.00
5760-100 100 µg
$255.00
More Sizes Get Quote

Product Details

Antibody Target ApoE2
Alternate Name Apolipoprotein E2, APOE 2, APOE-2, APOE2, Apolipoprotein E, AD2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E. coli expressed recombinant human ApoE2
Accession # NP_000032
Gene ID 348
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti- human ApoE2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot
Application & Usage Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human ApoE2 (Cat. # 4760-50) can be used as a positive control.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.


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