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ApoA-1, rat recombinant

A protein promoting cholesterol efflux from tissues to the liver 
Catalog #: 4695
SKU-Size Size Price Qty
4695-20 20 μg
$85.00
4695-100 100 μg
$205.00
4695-1000 1 mg
$1,650.00
More Sizes Get Quote

Product Details

Alternate Name APOA1, MGC117399, Apoa1, Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, apolipoprotein, apolipoproteins, MGC102525, Sep-1, Sep-2, Sep2, rat ApoA-1, ApoA-1, ApoA1, Apo A1, r-ApoA-1, rr-ApoA-1, recombinant rat ApoA-1, ApoA1, recombinant ApoA-1, ApoA1, Apolipoprotein
Gene Symbol Apoa-I
Gene ID 25081
Accession # NP_036870
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 27.4 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the “good cholesterol.” The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic Vascular diseases. Recombinant rat ApoA-I is a 27.4 kDa protein of 235 amino acid residues.


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