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Apo-J/Clusterin

A protein associated withclearance of cellular debris and apoptosis
Catalog #: 4325

In stock

SKU-Size Size Price Qty
4325-10 10 μg
$275.00
4325-500 500 μg
$7,140.00
More Sizes Get Quote

Product Details

Alternate Name CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, , MGC24903, Clusterin, Apolipoprotein J, Apo-J, Apolipoprotein, apolipoproteins, Aging-associated gene 4 protein, Complement cytolysis inhibitor, Complement-associated protein SP-40,40, Ku70-binding protein 1, N
Gene Symbol TRPM-2
Gene ID 1191
Accession # P10909
Source Plasma
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized from PBS, pH 7.5.
Molecular Weight 75-80 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Reconstitution Instructions Reconstitute in dH₂O to a working volume of 0.5 mg/ml and let the lyophilized pellet dissolve completely.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

Apoliprotein J (APO-J), also named Clusterin, is a 75-80 kD disulfide-linked heterodimeric protein. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the a and b chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic a-helices. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.


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