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Apigenin

A casein kinase II (CKII) inhibitor
Catalog #: 2508
SKU-Size Size Price Qty
2508-25 25 mg
$95.00
2508-100 100 mg
$285.00
More Sizes Get Quote

Product Details

Alternate Name 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Chamomile; Flavone; NSC 83244; Versulin
Appearance White solid
CAS # 520-36-5
Molecular Formula C₁₅H₁₀O₅
Molecular Weight 270.2
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml)
SMILES C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChi InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChi Key KZNIFHPLKGYRTM-UHFFFAOYSA-N
PubChem CID 5280443
MDL Number MFCD00006831
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A naturally occurring plant flavone that displays remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. It selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC₅₀ value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI 231 cells. At 5 µM, it is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.


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