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APG7/ATG7 Antibody

Catalog #: 3907
SKU-Size Size Price Qty
3907-30T 30 µg
$89.00
3907-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target ATG7/APG7
Alternate Name APG7L , ATG7 , DKFZp434N0735 , GSA7
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide near the N-terminus of rat APG7
Accession # NP_001012097
Gene ID 312647
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 0.5 mg/ml affinity purified rabbit anti-APG7/ATG7 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjμgation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been sμggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.


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