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APG12/ATG12 Antibody

Catalog #: 3912
SKU-Size Size Price Qty
3912-30T 30 µg
$89.00
3912-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target APG12/ATG12
Alternate Name APG12 , APG12L , ATG12 , HAPG12
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 21 of mouse APG12
Accession # Q9CQY1
Gene ID 67526
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 0.5 mg/ml affinity purified rabbit anti-APG12 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjμgate with ATG5; this conjμgate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjμgate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.


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