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APD-597

A second generation agonist of the orphan G-protein coupled receptor GPR119
Catalog #: 9637
SKU-Size Size Price Qty
9637-10 10 mg
$145.00
9637-50 50 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name Propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate; JNJ-38431055
Appearance Crystalline solid
CAS # 897732-93-3
Molecular Formula C₂₁H₂₉N₅O₆S
Molecular Weight 479.55
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=C(C=CC(=N1)S(=O)(=O)C)NC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)OC
InChi InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
InChi Key WPDCHTSXOPUOII-UHFFFAOYSA-N
PubChem CID 11691484
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

APD-597 is a GPR119 agonist with EC₅₀ of 46 nM for hGPR119. Could be a potential anti-diabetic agent for treatment of type 2 diabetes.


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