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Anti-WT1 Antibody

Affinity purified Rabbit polyclonal to WT1
Catalog #: A1875
$325.00

Product Details

Cat # +Size A1875-100
Size 100 µl
Antibody Target WT1
Alternate Name WIT-2, GUD, AWT1, Wilms tumor 1, NPHS4, EWS-WT1, WT1, WAGR, WT33
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human WT1 (NP_001185480.1).
Accession # P19544
Gene ID 7490
Appearance Liquid
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Affinity purification
Species Reactivity Rat, Mouse, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Application & Usage IHC 1:50 - 1:200, IF 1:50 - 1:200, WB 1:500 - 1:2000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.


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