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Product Details
| Cat # +Size | A1045-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | VEGF |
| Alternate Name | Avastin |
| Host | Recombinant |
| Antibody Type | Monoclonal |
| Isotype | Human IgG1 |
| Immunogen | Recombinant human VEGF |
| Accession # | AAP86646 |
| Gene ID | 7422 |
| Appearance | Colourless liquid |
| Concentration | 1 mg/ml |
| Formulation | 100 ug of antibody in Phosphate buffered saline, pH 7.4. |
| Purification | human IgG1 was expressed in a human cell line. IgG was purified from CHO cell culture supernatant by protein A chromatography. |
| Species Reactivity | Human |
| Application | Neutralization, ELISA |
| Application & Usage | Neutralization: 0.1-20 μg/ml, ELISA: 2 μg/ml |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Bevacizumab (Avastin) is a recombinant humanized monoclonal IgG1 antibody. Bevacizumab, targets the cell surface protein called vascular endothelial growth factor (VEGF) results in suppression of tumor growth. VEGF plays an essential role in developmental angiogenesis and is also important for reproductive and bone angiogenesis. Avastin is used to treat various cancers like metastatic colorectal cancer, non-squamous non–small cell lung cancer, metastatic breast cancer, glioblastoma and metastatic renal cell carcinoma.
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