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Anti-VEGF-A (Brolucizumab), Humanized Antibody

The biosimilar is a humanized scFv antibody fragment that targets VEGF-A and prevents neovascularization and proliferation of endothelial cells. The original monoclonal antibody is approved to treat wet age-related macular degeneration
Catalog #: A2221
$465.00

Product Details

Cat # +Size A2221-100
Size 100 μg
Antibody Target VEGFA
Alternate Name ESBA-1008, ESBA1008, RTH-258, RTH258, VPF, VEGF, MVCD1, VEGFA
Host Recombinant
Antibody Type Monoclonal
Isotype scFv-kappa-heavy
Immunogen Human VEGFA
Accession # DB14864
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a humanized single-chain Fv (scFv) antibody fragment that targets vascular endothelial growth factor A (VEGF-A). VEGF-A is a pro-angiogenic protein that plays a significant role in the pathogenesis of several diseases such as age-related macular degeneration, cancer, and diabetic retinopathy. Binding of VEGF-A to its receptor activates several downstream proteins such as PI3K, Ras, and MAPK, and promotes proliferation, growth, and migration of endothelial cells. The antibody binds to VEGF-A and prevents binding to its receptors, thereby inhibiting neovascularization, vascular permeability, and proliferation of endothelial cells. The small size of the antibody not only allows it to retain the ability to bind to its target protein, but also provides efficient penetration into the retina and choroid, and faster clearance from the system. The original antibody received approval from the FDA to treat wet age-related macular degeneration


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