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Anti-USP2 Antibody

Rabbit polyclonal antibody to detect the expression of USP2 in human and mouse samples
Shelf Life: 12 months
Catalog #: A2146
$335.00

Product Details

Cat # +Size A2146-100
Size 100 μg
Antibody Target USP2
Alternate Name 41 kDa ubiquitin specific protease, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin carboxyl terminal hydrolase 2, Ubiquitin carboxyl-terminal hydrolase 2, ubiquitin specific peptidase 2, Ubiquitin specific processing protease 2, Ubiquitin specific protease 12, Ubiquitin specific protease 9, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease, UBP-t, UBP2, UBP41, USP2, USP9
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant Human Ubiquitin carboxyl-terminal hydrolase 2 protein
Accession # O75604
Gene ID 9099
Appearance Colorless liquid
Formulation In 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300
Purification Protein G purified
Species Reactivity Human, Mouse
Application Western Blotting, Immunofluorescence (IF)
Application & Usage WB 1:1000-1:5000, IF 1:50-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease that is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX, and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.


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