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Anti-Ubiquitin Antibody

Polyclonal antibody to detect endogenous levels of Ubiquitin in human, mouse and rat samples
Catalog #: A1702
$395.00

Product Details

Cat # +Size A1702-100
Size 100 µl
Antibody Target Ubiquitin
Alternate Name Polyubiquitin-B, UBB
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant protein of human UBB
Accession # P0CG47
Gene ID 7314
Appearance Colorless liquid
Concentration 0.3 mg/mL
Formulation In PBS with 0.05% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Rat,Mouse,Human
Application Immunohistochemistry (IHC),Western Blotting
Application & Usage WB 1:500-1:2000,IHC 1:25-1:100
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.


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