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Anti-Toxin B (Bezlotoxumab), Human IgG1 Antibody

The biosimilar is a human monoclonal antibody that targets and inhibits the binding of Clostridium difficile toxin B to mammalian host cells
Catalog #: A2220
$465.00

Product Details

Cat # +Size A2220-100
Size 100 μg
Antibody Target Toxin B
Alternate Name MBL-CDB1, MK-6072, CDB-1, MDX-1388, MK-3415A, tcdB, glycosylating toxin TcdB
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Clostridium difficile Toxin B
Accession # P18177/DB13140
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Clostridium difficile
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a human monoclonal antibody that targets Clostridium difficile toxin B. Toxin B (TcdB) is a glucosyltransferase protein that glucosylates small GTPases such as Rho, Rac, and Cdc42 in the target cells. The toxin is known to disrupt the actin cytoskeleton of the cells by causing condensation of the actin, blebbing of the membrane, which eventually leads to apoptosis and cell death. The antibody binds to the two epitopes on the N-terminal of the Toxin B CROP domain via its two Fab regions, thus partially blocking carbohydrate-binding pockets and prevents the binding of the toxin to the host cells. The original monoclonal antibody was approved by the FDA to treat adult patients who are either receiving antibacterial treatment for Clostridium difficile infection (CDI) or are at a high risk of getting re-infected with CDI


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