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Anti-TNSF13B (Belimumab), Human IgG1 Antibody

The biosimilar is a fully human recombinant monoclonal antibody that targets soluble human B lymphocyte stimulator protein (BLyS), prevents the binding with its receptor on B lymphocyte cell surface and inhibits B-cell mediated immune response
Catalog #: A2170
$455.00

Product Details

Cat # +Size A2170-100
Size 100 μg
Antibody Target TNFSF13B
Alternate Name LymphoStat B, LymphoStat-B, DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNLG7A, TNFSF20
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, lambda
Immunogen Human TNFSF13B
Accession # DB08879
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Application In vitro studies
Application & Usage In vitro studies
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant fully human IgG1 monoclonal antibody that specifically binds to soluble human B lymphocyte stimulator protein (BLyS), also known as B-cell activating factor (BAFF). BAFF belongs to the superfamily of Tumor Necrosis Factor (TNF) and plays a vital role in B-cell maturation and survival. It is produced by several cell types such as neutrophils, dendritic cells, and macrophages. Binding of BLyS to its receptors on the surface of B-cells activates downstream signaling pathways such as NF-κB and MAPK pathways that promote the expression of anti-apoptotic proteins and inhibit apoptosis. The antibody binds to BLyS, prevents the association with its receptors, and thereby reduces the survival of autoantibody-producing B-cells. The original drug received approval from the FDA to treat systemic lupus erythematosus.


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