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Anti-TNFSF11, Human IgG2 Antibody

Biosimilar to Denosumab, monoclonal antibody that targets TNFSF11
Catalog #: A2150
$455.00

Product Details

Cat # +Size A2150-100
Size 100 μg
Antibody Target TNFSF11
Alternate Name CD254, ODF, OPGL, sOdf, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2
Host Recombinant
Antibody Type Monoclonal
Isotype IgG2, kappa
Immunogen Human TNFSF11
Accession # DB06643
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a fully human IgG2 monoclonal antibody that specifically targets receptor activator of nuclear factor kappa-B ligand (RANKL, also known as TNFSF11), a protein that plays a key role in the formation, function, and survival of osteoclasts. RANKL belongs to the TNF superfamily of ligands. Interaction with the receptor (RANK) expressed on pre-osteoclast and mature osteoclast cells results in the activation, migration, differentiation, and fusion of hematopoietic cells of osteoclast lineage, and promotes bone resorption. RANKL is also shown to be a dendritic cell survival factor and is involved in the regulation of T cell-dependent immune response.


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