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Anti-TNF alpha (Infliximab), Human IgG1 Antibody

Monoclonal antibody to detect TNF alpha in human samples.
Catalog #: A1097
$670.00

Product Details

Cat # +Size A1097-200
Size 200 µg
Antibody Target TNF
Alternate Name TNF-α; TNFα; TNFSF; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; TNFa
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG1, kappa
Immunogen Purified recombinant human TNF (rTNF)
Accession # P01375
Gene ID 7124
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification Affinity purified using protein A
Species Reactivity Human
Application ELISA; in vivo; FC
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line.


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