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Anti-TMPRSS2 Antibody

Affinity purified rabbit polyclonal antibody to detect the expression of Transmembrane serine protease 2 in human, mouse and rat samples
Catalog #: A2102
$340.00

Product Details

Cat # +Size A2102-100
Size 100 μl
Antibody Target TMPRSS2
Alternate Name PRSS10; Transmembrane protease serine 2; Serine protease 10, PP9284, Serine protease 10 antibody, TMPRSS2, TMPS2
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant full length protein of human TMPRSS2
Gene ID 7113
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Mouse, Rat, Human
Application Immunohistochemistry (IHC), Western Blotting
Application & Usage WB 1:500 - 1:2000, IHC 1:50 - 1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


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