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Anti-TIGIT, Rabbit IgG, kappa Antibody

Recombinant monoclonal antibody manufactured using Recombinant Platform with variable regions from the hybridoma 4D4 to detect TIGIT expression in mouse. 4D4 is an agonistic anti-TIGIT antibody, and addition of anti-CD3/anti-CD28 stimulated T cells to plate bound 4D4 is known to inhibit their proliferation. Further, 4D4 has been used in order to identify genes that are downstream of TIGIT signaling in Tregs, as TIGIT engagement might modulate the Treg phenotype in tumor tissue.
Catalog #: A2018
$455.00

Product Details

Cat # +Size A2018-200
Size 200 µg
Antibody Target TIGIT
Alternate Name T Cell Immunoreceptor With Ig And ITIM Domains; V-Set And Immunoglobulin Domain Containing Protein 9; V-Set And Transmembrane Domain Containing Protein 3; VSIG9; VSTM3; T Cell Immunoreceptor With Ig And ITIM Domains; Washington University Cell Adhesion Molecule; WUCAM
Host Recombinant
Antibody Type Monoclonal
Isotype Rabbit IgG, kappa
Immunogen Armenian hamsters were immunized with recombinant mouse TIGIT tetramers by a combination of s.c. and food pad immunization and booster injections. Draining lymph nodes were fused with Sp2/0-Ag14 cells, selected in HAT medium and supernatants were screened
Accession # P86176
Gene ID 201633
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS with 0.02% Proclin 300
Purification Protein A affinity purified
Species Reactivity Mouse
Application Agonist, Flow Cytometry
Handling The antibody solution should be gently mixed before use.
Storage Conditions Store at -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Recombinant monoclonal antibody to TIGIT. T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3, is a type I transmembrane protein, which belongs to the PVR family of immunoglobulin-like domain containing proteins. It is composed of an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on activated T cells, follicular T helper, memory T cells, and regulatory T cells and NK cells. TIGIT binds to CD155 (PVR) with high affinity and it regulates T-cell mediated immunity via the CD226/TIGIT-PVR pathway. TIGIT also serves as a negative regulator of NK and T cell activation.


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