Product Details
| Cat # +Size | A1670-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | STAT3 |
| Alternate Name | Signal transducer and activator of transcription 3, stat -3, STAT3, STAT -3, STAT 3, APRF , FLJ20882 , MGC16063 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | A synthesized peptide derived from human STAT3 |
| Accession # | P40763 |
| Gene ID | 6774 |
| Appearance | Colorless liquid |
| Concentration | 1 mg/ml |
| Formulation | In phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol |
| Purification | Affinity purified |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB,IHC, ICC/IF, ELISA |
| Positive Control | WB: K562 cell lysates, IF/ICC: LOVE cells, IHC: pancreas tissue |
| Application & Usage | WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Althoμgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
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