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Anti-STAT3 Antibody

Polyclonal antibody to detect endogenous levels of STAT3 in human, mouse and rat samples
Catalog #: A1670

In stock

$395.00

Product Details

Cat # +Size A1670-100
Size 100 µl
Antibody Target STAT3
Alternate Name Signal transducer and activator of transcription 3, stat -3, STAT3, STAT -3, STAT 3, APRF , FLJ20882 , MGC16063
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen A synthesized peptide derived from human STAT3
Accession # P40763
Gene ID 6774
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB,IHC, ICC/IF, ELISA
Positive Control WB: K562 cell lysates, IF/ICC: LOVE cells, IHC: pancreas tissue
Application & Usage WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Althoμgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.


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