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Anti- STAT1 Antibody

Polyclonal antibody to detect endogenous levels of STAT1 in human, mouse and rat.
Catalog #: A1215
$325.00

Product Details

Cat # +Size A1215-100
Size 100 µl
Antibody Target STAT1
Alternate Name Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the center region of human STAT1
Accession # P42224
Gene ID 6772
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB
Positive Control WB; HEK293T, RAW264.7, H9C2 cell lysate
Application & Usage WB; 1:500 – 1:2000
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4


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