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Anti-ST2 Capture Antibody

Protein A purified mouse monoclonal antibody to detect ST2 in humans. This antibody is match-paired with Anti-ST2 Detection Antibody (Catalog# A2099) and can be used for applications such as ELISA, Lateral Flow and Chemiluminescence immunoassay (CLIA)
Catalog #: A2098
$310.00

Product Details

Cat # +Size A2098-100
Size 100 μg
Antibody Target ST2
Host Mouse
Antibody Type Monoclonal
Isotype IgG1
Immunogen Recombinant ST2
Appearance Colorless liquid
Formulation In 10 mM PBS, pH 7.4, 0.02% Proclin 300
Purification Protein A purified
Species Reactivity Human
Application ELISA, Lateral Flow, CLIA
Application & Usage ELISA, Lateral Flow, CLIA
Handling The antibody solution should be gently mixed before use.
Storage Conditions 2-8°C (Short term), -20°C (Long term)
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Suppressor of tumorigenicity (ST2) belongs to the interleukin 1 family of receptors. It exists in two isoforms: soluble form (sST2) found circulating in the plasma and transmembrane receptor form (ST2L). This protein is expressed by cardiomyocytes and vascular endothelial cells. Binding of ST2L to its ligand IL-33, prevents hypertrophy of the myocardium and fibrosis. However, sST2 competes with ST2L to bind to IL-33 and upon binding its ligand, neutralizes the cardioprotective effects of IL-33 and ST2L. Elevated levels of sST2 are associated with ventricular remodeling, fibrosis and chronic heart failure.


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