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Anti-Smad4 Rabbit Monoclonal Antibody

Monoclonal antibody to detect Smad4 in human samples.
Catalog #: A1605

In stock

$295.00

Product Details

Cat # +Size A1605-50
Size 50 µl
Antibody Target Smad4
Alternate Name SMAD family member, Mothers against decapentaplegic homolog, MAD homolog, Mothers against DPP homolog, SMAD4
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the C-terminus of human Smad4
Accession # Q9BYG6
Gene ID 4089
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Affinity purified
Species Reactivity Human
Application WB, IHC
Positive Control WB: Jurkat and IMR32 cells lysates, IHC: human breast cancer tissue
Application & Usage WB: 1:500-1:1000, IHC: 1:1000-1:2000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF-β and activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities throμgh interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.


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