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Anti-SMAD2/3 Antibody

Polyclonal antibody to detect endogenous levels of SMAD2/3 in human, mouse and rat.
Catalog #: A1214
$325.00

Product Details

Cat # +Size A1214-100
Size 100 µl
Antibody Target SMAD2/SMAD3
Alternate Name SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SMAD2/3
Accession # Q15796, P84022
Gene ID 4087, 4088
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB
Positive Control WB; Hela, NIH3T3, PC12 cell lysates
Application & Usage WB; 1:500 – 1:2000
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.


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