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Anti-SIRT7 Antibody

Polyclonal Antibody to detect SIRT7 in human samples
Catalog #: A1457

In stock

SKU-Size Size Price Qty
A1457-30T 30 µg
$89.00
A1457-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target SIRT7
Alternate Name NAD-dependent deacetylase 7, SIR2-like protein 7, Sirtuin 7, SIR2L7, Silent Information Regulator 7
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Human recombinant SIRT7
Accession # Q9NRC8
Gene ID 51547
Appearance Colorless liquid
Formulation In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% Proclin
Purification Affinity purified
Species Reactivity Human
Application WB
Positive Control WB: SIRT7 human recombinant
Application & Usage WB: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The sirtuins represent a distinct class of trichostatin A-insensitive lysyldeacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart. This antibody especially recognizes the cleaved sirtuin-7.


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