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Anti-SIRT1 Polyclonal Antibody

Coordinates cellular functions including cell cycle regulation, metabolism, apoptosis, and autophagy
Catalog #: A2345
SKU-Size Size Price Qty
A2345-50 50 µl
$185.00
A2345-100 100 µl
$325.00
More Sizes Get Quote

Product Details

Antibody Target Human SIRT1
Alternate Name Sirtuin 1; SIR2L1; SIR2-Like Protein 1; Sirtuin Type 1; HSIRT1; HSIR2; SIR2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide of human SIRT1
Accession # Q96EB6
Gene ID 23411
Appearance Liquid
Formulation In 0.42% potassium phosphate, 0.87% NaCl, pH 7.3, w/30% glycerol and 0.01% sodium azide
Purification Immunogen affinity chromatography
Species Reactivity Rat, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Sirtuin 1 (SIRT1) is an NAD-dependent protein deacetylase that links transcriptional regulation directly to myriad cellular functions such as cell cycle control, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through histone deacetylation which leads to transcriptional repression of target genes. SIRT1 can also directly deacetylate transcription factors, which positively and negatively regulates target gene expression depending on the affected transcription factor. Among the proteins affected by SIRT1 are ARNTL, PER2, and CRY1, demonstrating a key role for SIRT1 in the regulation of circadian rhythm.


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