Product Details
| Cat # +Size | A2128-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | SHP2 |
| Alternate Name | BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2; PTPN11 |
| Host | Rabbit |
| Antibody Type | Monoclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide derived from human SHP2 |
| Accession # | Q06124 |
| Gene ID | 5781 |
| Appearance | Colorless liquid |
| Formulation | In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3 |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | Western Blotting |
| Application & Usage | WB 1:500 - 1:2000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
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