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Anti-SHH Antibody

Polyclonal antibody to detect endogenous levels of SHH in human, mouse and rat sample
Catalog #: A1695
$395.00

Product Details

Cat # +Size A1695-100
Size 100 µl
Antibody Target SHH
Alternate Name HHG 1,HHG-1,HHG1,HLP 3,HLP3,Holoprosencephaly 3,HPE 3,HPE3,MCOPCB5,shh,SHH,SMMC I,SMMCI,Sonic Hedgehog (Drosophila) homolog,sonic hedgehog homolog (Drosophila),Sonic hedgehog homolog,Sonic hedgehog protein,Sonic hedgehog protein C-product,TPT,TPTPS
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Synthetic peptide of human SHH
Accession # Q15465
Gene ID 6469
Appearance Colorless liquid
Concentration 0.5 mg/mL
Formulation In PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification Affinity purification
Species Reactivity Rat,Mouse,Human
Application Immunohistochemistry (IHC),ELISA
Application & Usage ELISA,IHC 1:50-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.


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