Anti-SFTPD Antibody

Rabbit polyclonal antibody to detect Surfactant Protein D (SFTPD) in human samples
Catalog #: A2253 | abID:

Product Details

Cat # +Size A2253-100
Size 100 μg
Antibody Target SFTPD
Alternate Name SP-D, PSP-D, SFTP4, COLEC7, SFTPD
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Fusion protein of Human SFTPD
Accession # P35247
Gene ID 6441
Appearance Colorless liquid
Formulation In PBS, pH 7.4, 40% glycerol, 0.05% sodium azide
Purification Antigen Affinity purified
Species Reactivity Human
Application Immunohistochemistry (IHC)
Application & Usage IHC 1:25-1:100
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Surfactant protein D is a 43 kDa glycoprotein that belongs to the family of collectins, which are a group of collagen-containing C-type lectins. The protein is synthesized and secreted by alveolar type II cells and non-ciliated airway cells. The gene for SP-D, SFTPD, is located on the long arm of the chromosome 10q22.2-23.1. SFTPD plays a significant role in innate immune response and protects the lungs from inhaled microorganisms, toxins, and organic antigens. It binds to a variety of phospholipids, polysaccharides, and glycolipids located on the surface of bacteria, viruses, and allergens and promote the killing of these pathogens by phagocytosis. Increased levels of SP-D are associated with the development, progression, and severity of pulmonary diseases such as COPD, idiopathic pulmonary fibrosis, and acute respiratory distress syndrome (ARDS). Therefore it is considered a promising biomarker for lung inflammation and pulmonary diseases


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