Product Details
| Cat # +Size | A2253-100 |
|---|---|
| Size | 100 μg |
| Antibody Target | SFTPD |
| Alternate Name | SP-D, PSP-D, SFTP4, COLEC7, SFTPD |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Immunogen | Fusion protein of Human SFTPD |
| Accession # | P35247 |
| Gene ID | 6441 |
| Appearance | Colorless liquid |
| Formulation | In PBS, pH 7.4, 40% glycerol, 0.05% sodium azide |
| Purification | Antigen Affinity purified |
| Species Reactivity | Human |
| Application | Immunohistochemistry (IHC) |
| Application & Usage | IHC 1:25-1:100 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Surfactant protein D is a 43 kDa glycoprotein that belongs to the family of collectins, which are a group of collagen-containing C-type lectins. The protein is synthesized and secreted by alveolar type II cells and non-ciliated airway cells. The gene for SP-D, SFTPD, is located on the long arm of the chromosome 10q22.2-23.1. SFTPD plays a significant role in innate immune response and protects the lungs from inhaled microorganisms, toxins, and organic antigens. It binds to a variety of phospholipids, polysaccharides, and glycolipids located on the surface of bacteria, viruses, and allergens and promote the killing of these pathogens by phagocytosis. Increased levels of SP-D are associated with the development, progression, and severity of pulmonary diseases such as COPD, idiopathic pulmonary fibrosis, and acute respiratory distress syndrome (ARDS). Therefore it is considered a promising biomarker for lung inflammation and pulmonary diseases
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