Anti-SARS-CoV-2 Spike S1 Antibody

Rabbit polyclonal antibody to detect the expression of SARS-CoV-2 Spike Protein S1. This antibody can be match-paired with Anti-SARS-CoV-2 Spike S1 antibody (Clone# 4C6) (Catalog# A3001) for Sandwich ELISA
Catalog #: A3000 | abID: ab286145

Product Details

abID ab286145
Cat # +Size A3000-50
Size 50 μg
Antibody Target SARS-CoV-2 Spike S1
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen CHO-expressed full length S1 with human IgG Fc fusion
Appearance Colorless liquid
Formulation 0.01 M Tris-HCl, pH 8.0, 0.15 M NaCl, 0.02% sodium azide
Purification Protein A purified
Application Virus Neutralizing Assay, ELISA
Application & Usage Indirect ELISA (0.05 - 1 μg/ml), Sandwich ELISA (0.25 - 1 μg/ml) as coating antibody with Anti-SARS-CoV-2 Spike S1 antibody (Clone 4C6) (Catalog# A3001), Virus Neutralizing Assay (titer at 20 μg/ml)
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Coronaviruses (CoV) are a large group of enveloped positive-sense RNA viruses. They belong to subfamily Coronavirinae, in the family of Coronaviridae, of the order of Nidovirales. The Coronavirus genome is about 30 kb in length and encodes four structural proteins, namely, spike (S), envelope (E), membrane (M) and nucleocapsid (N), multiple nonstructural proteins and other accessory proteins. The Spike (S) protein is a 180 kDa type I glycosylated transmembrane protein, that assembles as a trimer on the surface of the virus, hence the coronavirus appears crown-shaped (In Latin, corona means crown). The ectodomain of the Spike protein consists of two domains: S1 domain whose main function is receptor binding, and S2 domain whose main function is membrane fusion. S1 binds to the cell surface receptor of host for attachment during the viral entry, this induces conformational change in the S2, thus enabling the fusion of host and viral membranes and ultimately entry of the viral genome in the host cell.

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Ramesh K. Paidi. ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy. J Neuroimmune Pharmacol. Jan 2021. 33426604.
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