Product Details
| abID | ab286145 |
|---|---|
| Cat # +Size | A3000-50 |
| Size | 50 μg |
| Antibody Target | SARS-CoV-2 Spike S1 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Immunogen | CHO-expressed full length S1 with human IgG Fc fusion |
| Appearance | Colorless liquid |
| Formulation | 0.01 M Tris-HCl, pH 8.0, 0.15 M NaCl, 0.02% sodium azide |
| Purification | Protein A purified |
| Application | Virus Neutralizing Assay, ELISA |
| Application & Usage | Indirect ELISA (0.05 - 1 μg/ml), Sandwich ELISA (0.25 - 1 μg/ml) as coating antibody with Anti-SARS-CoV-2 Spike S1 antibody (Clone 4C6) (Catalog# A3001), Virus Neutralizing Assay (titer at 20 μg/ml) |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Coronaviruses (CoV) are a large group of enveloped positive-sense RNA viruses. They belong to subfamily Coronavirinae, in the family of Coronaviridae, of the order of Nidovirales. The Coronavirus genome is about 30 kb in length and encodes four structural proteins, namely, spike (S), envelope (E), membrane (M) and nucleocapsid (N), multiple nonstructural proteins and other accessory proteins. The Spike (S) protein is a 180 kDa type I glycosylated transmembrane protein, that assembles as a trimer on the surface of the virus, hence the coronavirus appears crown-shaped (In Latin, corona means crown). The ectodomain of the Spike protein consists of two domains: S1 domain whose main function is receptor binding, and S2 domain whose main function is membrane fusion. S1 binds to the cell surface receptor of host for attachment during the viral entry, this induces conformational change in the S2, thus enabling the fusion of host and viral membranes and ultimately entry of the viral genome in the host cell.
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
Ramesh K. Paidi. ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy. J Neuroimmune Pharmacol. Jan 2021. 33426604.
For more citations of this product click here
