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Anti-SARS-CoV-2 S2 Antibody (Clone# AbH722)

Recombinant monoclonal antibody (Clone# AbH722) to detect the expression of SARS-CoV-2 Spike S2 protein
Catalog #: A2268

Product Details

Cat # +Size A2268-100
Size 100 μg
Antibody Target SARS-CoV-2 Spike S2
Alternate Name Spike protein, COVID19, COVID 19, S protein, SARS-CoV S protein, S glycoprotein, E2, Peplomer protein, Spike protein S1, SARS Coronavirus, SARS-CoV-2, SARS CoV 2, 2019-nCoV, Spike protein S2, S2 protein, AbH722
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG
Immunogen Recombinant SARS-CoV-2 S2 protein
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Species Reactivity Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV
Handling The antibody solution should be gently mixed before use.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The Spike protein (S) is a type I membrane fusion protein required for viral infection and pathogenesis. It is synthesized as a precursor protein between 1200 to 1300 amino acids. The mature protein is a heavily glycosylated trimer with 21-35 glycosylation sites. Upon cleavage by host proteases, it yields 2 subunits, S1 and S2. The S1 subunit consists of 672 amino acids and is divided into 4 domains: an N-terminal domain, a C-terminal domain (also called receptor binding domain, RBD), and 2 subdomains SD1 and SD2. The S2 subunit consists of 588 amino acids and is divided into 4 domains: an N-terminal hydrophobic fusion peptide (FP), 2 heptad repeats (HR1 and HR2), a transmembrane domain (TM), and a cytoplasmic tail. When S1 recognizes and binds to the host receptor, the S2 subunit undergoes a conformational change to bring about the fusion of viral envelope and host cell membrane. Current strategies involve the development of anti-viral drugs to inhibit infection of coronavirus.

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