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Anti-SARS-CoV-2 RBD-02 Humanized Antibody

A humanized monoclonal antibody targeting the SARS-CoV-2 spike protein receptor binding domain, in tandem with Anti-SARS-CoV-2 RBD-01
Catalog #: A2354
SKU-Size Size Price Qty
A2354-50 50 µg
$385.00
A2354-100 100 µg
$495.00
More Sizes Get Quote

Product Details

Antibody Target Receptor binding domain of SARS-CoV-2 spike protein
Alternate Name COVID-19 Spike RBD protein; 2019-nCoV Spike RBD protein
Host XtenCHO cells
Antibody Type Monoclonal
Isotype Humanized IgG1
Immunogen Receptor binding domain of SARS-CoV-2 spike protein
Appearance Liquid
Formulation In PBS, pH 7.5
Species Reactivity SARS-CoV-2
Application ELISA
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC (6 months), -80ºC (Long term)
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The spike (S) glycoprotein of coronaviruses mediates entry into receptor-expressing host cells and plays the most important role in viral attachment, fusion, and entry; therefore, it serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives membrane fusion and eventual entry of the virus. Within the S1 protein, the highly conserved receptor-binding domain (RBD) expresses a high affinity for the Angiotensin converting enzyme 2 receptor (ACE2). The original biosimilar was designed to target the RBD at different epitopes in tandem with Anti-SARS-CoV-2 RBD-01 (Cat. No. A2353) in order to reduce drug resistance during COVID-19 therapeutic trials.


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