Product Details
| Cat # +Size | A2259-100 |
|---|---|
| Size | 100 μg |
| Antibody Target | ORF7a |
| Alternate Name | ORF7a, Accessory protein 7a, Protein U122, Protein X4, ORF7a protein |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Immunogen | Amino acids 1-100 of ORF7a protein |
| Accession # | P0DTC7 |
| Appearance | Colorless liquid |
| Formulation | In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300 |
| Species Reactivity | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| Handling | The antibody solution should be gently mixed before use. |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is an infectious disease caused by a novel beta-coronavirus called SARS-CoV-2. The SARS-CoV-2 is a large enveloped, positive-sense RNA with a genome about ~ 30 kb long. The genome encodes 11 open reading frames. The open reading frame ORF7a is a type I transmembrane protein that codes for viral non-structural (accessory) proteins of unknown function. It is localized to the Golgi apparatus but may also be found on cell surfaces. In comparison with ORF7a of SARS-CoV, it has a sequence identity of 85.2% and a sequence similarity of 95.9%. Due to overlap with ORF7b, ORF7a shares a transcriptional regulatory sequence. ORF7a possesses a 15 amino acid N-terminal signal peptide, an 81 amino acid luminal domain, a 21 amino acid transmembrane domain, and a 5 amino acid cytoplasmic tail. A recent study demonstrated that SARS-CoV ORF7a acts as an antagonist to Bone marrow stromal antigen 2 (BST-2) antiviral activities. ORF7a extracellular domain binds to the unglycosylated extracellular domain of BST-2 in the Golgi apparatus and prevents N-linked glycosylation that is necessary for BST-2 antiviral activity.
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