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Anti-SARS-CoV-2 NSP12 Antibody

Rabbit polyclonal antibody to detect SARS-CoV-2 NSP12 protein
Catalog #: A2264
$365.00

Product Details

Cat # +Size A2264-100
Size 100 μg
Antibody Target NSP12
Alternate Name RNA-directed RNA polymerase, Pol, RdRp, Non-structural protein 12, Replicase polyprotein 1ab, NSP12
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant SARS-CoV-2 NSP12
Accession # P0DTD1
Appearance Colorless liquid
Formulation In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300
Species Reactivity Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Application Western Blotting
Application & Usage WB 1:1000
Handling The antibody solution should be gently mixed before use.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is an infectious disease caused by a novel beta-coronavirus called SARS-CoV-2. The SARS-CoV-2 is a large enveloped, positive-sense RNA with a genome about ~ 30 kb long. The genome encodes 14 open reading frames, of which ORF1a and ORF1b are translated to 2 polyproteins. The 2 polyproteins undergo autoproteolysis to yield 16 non-structural proteins (NSP1-16). NSP12 plays a key role in replication/translation machinery. It is highly homologous to the SARS-CoV NSP12 (sequence identity: 96.4% and sequence similarity: 99.4%), indicating that the function and mechanism of action may be conserved. NSP12 is an RNA-dependent RNA polymerase that copies viral RNA. It has an extended N-terminal region that binds to 2 cofactors (NSP7 and NSP8) necessary for the polymerase function. Based on previous studies, the N-terminal of NSP12 has been demonstrated to possess nucleotidyltransferase activity. The RdRp domain is located in the C-terminal, which enables polymerase function. Studies also showed that NSP13 has 2 polymerase activities: primer-dependent and primer-independent RNA synthesis. Due to its pivotal role in viral replication, NSP12/RdRp is considered a primary target for anti-viral drug development.


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