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Product Details
| Cat # +Size | A2264-100 |
|---|---|
| Size | 100 μg |
| Antibody Target | NSP12 |
| Alternate Name | RNA-directed RNA polymerase, Pol, RdRp, Non-structural protein 12, Replicase polyprotein 1ab, NSP12 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant SARS-CoV-2 NSP12 |
| Accession # | P0DTD1 |
| Appearance | Colorless liquid |
| Formulation | In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300 |
| Species Reactivity | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| Application | Western Blotting |
| Application & Usage | WB 1:1000 |
| Handling | The antibody solution should be gently mixed before use. |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is an infectious disease caused by a novel beta-coronavirus called SARS-CoV-2. The SARS-CoV-2 is a large enveloped, positive-sense RNA with a genome about ~ 30 kb long. The genome encodes 14 open reading frames, of which ORF1a and ORF1b are translated to 2 polyproteins. The 2 polyproteins undergo autoproteolysis to yield 16 non-structural proteins (NSP1-16). NSP12 plays a key role in replication/translation machinery. It is highly homologous to the SARS-CoV NSP12 (sequence identity: 96.4% and sequence similarity: 99.4%), indicating that the function and mechanism of action may be conserved. NSP12 is an RNA-dependent RNA polymerase that copies viral RNA. It has an extended N-terminal region that binds to 2 cofactors (NSP7 and NSP8) necessary for the polymerase function. Based on previous studies, the N-terminal of NSP12 has been demonstrated to possess nucleotidyltransferase activity. The RdRp domain is located in the C-terminal, which enables polymerase function. Studies also showed that NSP13 has 2 polymerase activities: primer-dependent and primer-independent RNA synthesis. Due to its pivotal role in viral replication, NSP12/RdRp is considered a primary target for anti-viral drug development.
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