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Anti-SARS-CoV-2 NSP12 Antibody

Rabbit polyclonal antibody to detect SARS-CoV-2 NSP12 protein
Catalog #: A2264

Product Details

Cat # +Size A2264-100
Size 100 μg
Antibody Target NSP12
Alternate Name RNA-directed RNA polymerase, Pol, RdRp, Non-structural protein 12, Replicase polyprotein 1ab, NSP12
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant SARS-CoV-2 NSP12
Accession # P0DTD1
Appearance Colorless liquid
Formulation In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300
Species Reactivity Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Application Western Blotting
Application & Usage WB 1:1000
Handling The antibody solution should be gently mixed before use.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is an infectious disease caused by a novel beta-coronavirus called SARS-CoV-2. The SARS-CoV-2 is a large enveloped, positive-sense RNA with a genome about ~ 30 kb long. The genome encodes 14 open reading frames, of which ORF1a and ORF1b are translated to 2 polyproteins. The 2 polyproteins undergo autoproteolysis to yield 16 non-structural proteins (NSP1-16). NSP12 plays a key role in replication/translation machinery. It is highly homologous to the SARS-CoV NSP12 (sequence identity: 96.4% and sequence similarity: 99.4%), indicating that the function and mechanism of action may be conserved. NSP12 is an RNA-dependent RNA polymerase that copies viral RNA. It has an extended N-terminal region that binds to 2 cofactors (NSP7 and NSP8) necessary for the polymerase function. Based on previous studies, the N-terminal of NSP12 has been demonstrated to possess nucleotidyltransferase activity. The RdRp domain is located in the C-terminal, which enables polymerase function. Studies also showed that NSP13 has 2 polymerase activities: primer-dependent and primer-independent RNA synthesis. Due to its pivotal role in viral replication, NSP12/RdRp is considered a primary target for anti-viral drug development.

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