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Product Details
| Cat # +Size | A2261-100 |
|---|---|
| Size | 100 μg |
| Antibody Target | Envelope (E) |
| Alternate Name | 2019-nCoV E protein, 2019-nCoV sM protein, Envelope small membrane protein, Envelope protein |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant SARS-CoV-2 E protein |
| Accession # | P0DTC4 |
| Appearance | Colorless liquid |
| Formulation | In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300 |
| Species Reactivity | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| Handling | The antibody solution should be gently mixed before use. |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Coronaviruses are large, enveloped, positive-sense RNA viruses that affect humans and a wide variety of mammals. These viruses have a genome length of 30 kb. The 5'-terminal of the viral genome encodes 2 polyproteins that cleave to yield several non-structural proteins. The 3'-terminal encodes 4 structural proteins, namely, Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N). Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence in some cases leads to aberrant virions or viral attenuation. The Envelope protein increases membrane permeability to ions and plays a central role in virus morphogenesis and assembly. It acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. It also plays a role in the induction of apoptosis. Envelope protein also activates the host NLRP3 inflammasome, leading to IL-1 beta overproduction.
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